Montelukast EP Impurity D CAS 1187586-61-3
| CAS No. | 1187586-61-3 |
| Molecular Formula | C41H46ClNO5S2 |
| Molecular Weight | 732.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Montelukast EP Impurity D (C41H46ClNO5S2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Montelukast EP Impurity D (CAS 1187586-61-3, C41H46ClNO5S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Montelukast EP Impurity D under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C41H46ClNO5S2 |
| Molecular Weight | 732.39 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Montelukast Standards
- Montelukast Impurity C07 (CAS 1242260-05-4)
- Montelukast EP Impurity E (CAS 1187586-58-8)
- Montelukast EP Impurity D Isomer (CAS CATO-C4X-10314)
- Montelukast Acyl-b-D-glucuronide (CAS 188717-17-1)
- Montelukast Methoxymethoxy Impurity (CAS 184764-27-0)
- Montelukast Sulfone (CAS 2714018-24-1)
- Montelukast Impurity 22 (CAS 1266620-74-9)
- Montelukast Impurity 9 (CAS CATO-C4X-10319)
Recommended Standards
- Ticagrelor impurity 28 (CAS 2205903-73-5)
- 2-Propenoic acid, 2-methyl-, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,14-pentacosafluorotetradecyl ester (CAS 6014-75-1)
- Sn(IV) Octaethylporphine dichloride (CAS 25777-43-9)
- (E)-6-Amino-5-(benzylideneamino)pyrimidine-2,4-diol (CAS 61885-37-8)
- Raltitrexed Impurity 41 (CAS CATO-C4X-138641)
- Levofloxacin Impurity 63 (CAS CATO-C4X-137163)
- Sodium Cromoglicate Impurity 27 (CAS CATO-C4X-201127)
- (6-Chloro-1H-indazol-4-yl)-methanol (CAS 2305079-31-4)
- Esmolol Impurity 23 (CAS CATO-C4X-189123)
- 8-Chloro-9H-purin-6-amine (CAS 28128-28-1)
- 4-(Hydrazinylmethyl)pyridazine (CAS 1363380-98-6)
- Ozagrel Impurity 23 (CAS 78712-44-4)
- 3-hydrazinyl-6-(1H-pyrazol-1-yl)pyridazine (CAS 70589-07-0)
- Insulin Degludec Impurity 5 (CAS CATO-C4X-21575)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com