Montelukast EP Impurity E CAS 1187586-58-8
| CAS No. | 1187586-58-8 |
| Molecular Formula | C41H46ClNO5S2 |
| Molecular Weight | 732.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Montelukast EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Montelukast EP Impurity E (CAS 1187586-58-8), a pharmacopoeial impurity reference standard (molecular formula C41H46ClNO5S2, MW 732.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Montelukast EP Impurity E is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 732.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C41H46ClNO5S2 |
| Molecular Weight | 732.39 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Montelukast Standards
- Montelukast Impurity C07 (CAS 1242260-05-4)
- Montelukast EP Impurity D (CAS 1187586-61-3)
- Montelukast EP Impurity D Isomer (CAS CATO-C4X-10314)
- Montelukast Acyl-b-D-glucuronide (CAS 188717-17-1)
- Montelukast Methoxymethoxy Impurity (CAS 184764-27-0)
- Montelukast Sulfone (CAS 2714018-24-1)
- Montelukast Impurity 22 (CAS 1266620-74-9)
- Montelukast Impurity 9 (CAS CATO-C4X-10319)
Recommended Standards
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- Busulfan Impurity 6 (CAS 928-51-8)
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