Rimegepant Impurity 17 CAS 1190363-50-8
| CAS No. | 1190363-50-8 |
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Rimegepant Impurity 17 (CAS 1190363-50-8, C25H35F2NO2Si) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rimegepant Impurity 17 (C25H35F2NO2Si) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 447.63 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Rimegepant Standards
- Rimegepant Impurity 145 (CAS CATO-C4X-2487145)
- Rimegepant Impurity 18 (CAS 1289023-95-5)
- Rimegepant Impurity 59 (CAS 1190363-47-3)
- Rimegepant Impurity 15 (CAS 1289024-42-5)
- Rimegepant Impurity 116 (CAS CATO-C4X-2487116)
- Rimegepant Impurity 125 (CAS CATO-C4X-2487125)
- Rimegepant Impurity 159 (CAS CATO-C4X-2487159)
- Rimegepant Impurity 160 (CAS CATO-C4X-2487160)
Recommended Standards
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- Clevidipine Impurity 36 (CAS CATO-C4X-101536)
- Tegoprazan impurity 44 (CAS 1640981-11-8)
- Cabazitaxel Impurity 26 (CAS 144790-01-2)
- 6-Bromo-1-chloroisoquinoline, 97% (CAS 205055-63-6)
- 4-Formylphenyl [1,1'-biphenyl]-4-carboxylate (CAS 303058-49-3)
- N-(2,2-Diphenylcyclopropyl)benzamide (CAS 4941-62-2)
- tert-Butyl 2-bromo-2-(triphenylphosphoranylidene)acetate (CAS 92748-54-4)
- Methyl 2-(6-bromo-2-methyl-4-oxoquinolin-1(4H)-yl)acetate (CAS 1216416-55-5)
- 2-(2-Chloro-6-ethylquinolin-3-yl)acetonitrile (CAS 1017356-07-8)
- Peptide 439 (CAS CATO-CPTD788439)
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