Rimegepant Impurity 18 CAS 1289023-95-5
| CAS No. | 1289023-95-5 |
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rimegepant Impurity 18 (CAS 1289023-95-5, C25H35F2NO2Si) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Rimegepant Impurity 18 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 447.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Rimegepant Standards
- Rimegepant Impurity 145 (CAS CATO-C4X-2487145)
- Rimegepant Impurity 17 (CAS 1190363-50-8)
- Rimegepant Impurity 59 (CAS 1190363-47-3)
- Rimegepant Impurity 15 (CAS 1289024-42-5)
- Rimegepant Impurity 116 (CAS CATO-C4X-2487116)
- Rimegepant Impurity 125 (CAS CATO-C4X-2487125)
- Rimegepant Impurity 159 (CAS CATO-C4X-2487159)
- Rimegepant Impurity 160 (CAS CATO-C4X-2487160)
Recommended Standards
- 1,3,5-Tris((pyridin-4-ylthio)methyl)benzene (CAS 862014-52-6)
- N-Isopropyl-2-((5-(4-(2-phenylbutanoyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 1105227-29-9)
- 3-Amino-6-ethyl-N-(5-(isobutylthio)-1,3,4-thiadiazol-2-yl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 625370-71-0)
- Viaminate (CAS 53839-71-7)
- Piracetam Impurity 13 (CAS 105-39-5)
- Meropenem Impurity 31 (CAS CATO-C4X-130931)
- Finerenone Impurity 141 (CAS CATO-C4X-2880141)
- 4-(2-Methoxyethyl)-3,5-dimethylisoxazole (CAS 83467-32-7)
- (4-((3,5-Dimethoxybenzyl)oxy)-3,5-dimethylphenyl)boronic acid (CAS 1072951-94-0)
- (D-Pro1??)-IL-1β (193-195) (human) (CAS 117027-34-6)
- 1-(6-Bromonaphthalen-2-yl)cyclopropan-1-amine (CAS 1704128-93-7)
- Styrene-α,β,β-d3 (stabilized with hydroquinone) (CAS 3814-93-5)
- 5-Bromo-2-(trifluoromethoxy)pyridin-4-amine (CAS 1361693-12-0)
- Anti-Inflammatory Peptide 1 (CAS 118850-71-8)
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