Rimegepant Impurity 145 CAS CATO-C4X-2487145
| CAS No. | CATO-C4X-2487145 |
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Rimegepant Impurity 145 (CAS CATO-C4X-2487145, C25H35F2NO2Si) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Rimegepant Impurity 145 (C25H35F2NO2Si) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Rimegepant Impurity 145 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Rimegepant Standards
- Rimegepant Impurity 17 (CAS 1190363-50-8)
- Rimegepant Impurity 18 (CAS 1289023-95-5)
- Rimegepant Impurity 59 (CAS 1190363-47-3)
- Rimegepant Impurity 15 (CAS 1289024-42-5)
- Rimegepant Impurity 116 (CAS CATO-C4X-2487116)
- Rimegepant Impurity 125 (CAS CATO-C4X-2487125)
- Rimegepant Impurity 159 (CAS CATO-C4X-2487159)
- Rimegepant Impurity 160 (CAS CATO-C4X-2487160)
Recommended Standards
- N-Isopropyl-2-((5-(4-(2-phenylbutanoyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 1105227-29-9)
- Viaminate (CAS 53839-71-7)
- Cholic Acid Impurity 3 (CAS CATO-C4X-11603)
- CAS 80846-41-9 (CAS 80846-41-9)
- Amphotericin B Impurity 23 (CAS CATO-C4X-184423)
- Lesinurad Impurity 15 (CAS 25033-19-6)
- Dimetindene EP Impurity C (CAS 92726-29-9)
- Methyl[(3-methyl-1h-1,2,4-triazol-5-yl)methyl]amine dihydrochloride (CAS 1333916-33-8)
- 2-Hydrazineyl-4-(methylthio)pyrimidine (CAS 946860-07-7)
- Linezolid Impurity 30 (CAS CATO-C4X-107330)
- ethyl trans-2-[(tert-butoxycarbonylamino)methyl]cyclopropanecarboxylate (CAS 946598-53-4)
- 4-Methylnicotinamide (CAS 7250-52-4)
- N-Cyclohexylphosphoric Triamide (CAS 25316-51-2)
- Semaglutide Impurity 14(Discontinued,See CPTD788307 ) (CAS CATO-C4X-222614)
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