Betamethasone impurity 70 CAS 1201919-11-0
| CAS No. | 1201919-11-0 |
| Molecular Formula | C22H28FO8P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Betamethasone impurity 70 (CAS 1201919-11-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H28FO8PNa and a molecular weight of 493.42 g/mol.
Betamethasone impurity 70 (C22H28FO8PNa) contains a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Betamethasone impurity 70 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28FO8P 2*Na |
| Molecular Weight | 493.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Betamethasone Standards
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- Betamethasone Impurity N22 (CAS 116522-68-0)
- Betamethasone Impurity 27 (CAS 116846-77-6)
- Betamethasone impurity 51 (CAS 1184871-61-1)
- Betamethasone Dipropionate EP Impurity G (CAS 1186048-33-8)
- Betamethasone Dipropionate impurity 02 (CAS 1186048-34-9)
Recommended Standards
- Chloroprocaine Impurity 5 (CAS CATO-C4X-32865)
- Rocuronium impurity 69 (CAS CATO-C4X-124269)
- Tigecycline Impurity 7 (CAS 1268494-40-1)
- 3-Cyclopropoxy-2-(methylamino)benzenesulfonamide (CAS 1243365-58-3)
- 2-Thioxo-2,3-dihydrobenzo[d]thiazole-6-sulfonic acid (CAS 29401-60-3)
- 3-(sec-Butyl)-5-((3-(3-methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one (CAS 623933-15-3)
- Imbricataflavone A (CAS 133336-96-6)
- N-(5-Formyl-4-phenylthiazol-2-yl)acetamide (CAS 89021-12-5)
- Ornidazole Impurity 45 (CAS CATO-C4X-133145)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
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