Betamethasone Impurity N22 CAS 116522-68-0
| CAS No. | 116522-68-0 |
| Molecular Formula | C22H27FO6 |
| Molecular Weight | 406.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Betamethasone Impurity N22 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 406.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Betamethasone Impurity N22 (CAS 116522-68-0, C22H27FO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Betamethasone Impurity N22 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H27FO6 |
| Molecular Weight | 406.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone impurity 53 (CAS CATO-C4X-143753)
- Betamethasone impurity 64 (CAS CATO-C4X-143764)
- Betamethasone impurity 51 (CAS 1184871-61-1)
- Betamethasone impurity 105 (CAS CATO-C4X-1437105)
- Betamethasone Impurity 89 (CAS CATO-C4X-143789)
- Betamethasone Impurity N1 (CAS 910-99-6)
- Betamethasone Impurity 112 (CAS CATO-C4X-1437112)
- Betamethasone Impurity 121 (CAS CATO-C4X-1437121)
Recommended Standards
- Fluvoxamine impurity 49 (CAS CATO-C4X-195149)
- N-(5-amino-2-fluorophenyl)-N-(phenylsulfonyl)benzenesulfonamide (CAS 1111507-12-0)
- Flurbiprofen Impurity 117 (CAS CATO-C4X-1444117)
- sulfo-SPDB (CAS 1193111-39-5)
- Doxapram Impurity 21 (CAS 14327-53-8)
- Samidorphan Impurity 9 (CAS 1000410-46-7)
- Solriamfetol Impurity 15 (CAS CATO-C4X-256315)
- (S)-2-Amino-N,3-dimethyl-N-(2-oxo-2-(pyrazin-2-yl)ethyl)butanamide (CAS 1354018-54-4)
- Methotrexate Impurity 35 (CAS CATO-C4X-115435)
- (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylbutanoate (2R)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]butanoate 433242-64-9 A826242 (CAS 433242-64-9)
- 5-Fluoro-2,6-dihydroxypyrimidine-4-carbaldehyde (CAS 20185-43-7)
- (R)-2-(aminomethyl)pentanoic acid hydrochloride (CAS 528566-21-4)
- 5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid (CAS 1352396-54-3)
- C-Peptide 2 (rat) (CAS 41594-08-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com