1-(2,2-Difluoroethyl)piperidine-2-carboxylic acid CAS 1218200-72-6
| CAS No. | 1218200-72-6 |
| Molecular Formula | C8H13F2NO2 |
| Molecular Weight | 193.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 193.19 g/mol gives 1-(2,2-Difluoroethyl)piperidine-2-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-(2,2-Difluoroethyl)piperidine-2-carboxylic acid (CAS 1218200-72-6) is a high-purity analytical reference standard with the molecular formula C8H13F2NO2 and a molecular weight of 193.19 g/mol.
The molecular framework of 1-(2,2-Difluoroethyl)piperidine-2-carboxylic acid (C8H13F2NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-(2,2-Difluoroethyl)piperidine-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H13F2NO2 |
| Molecular Weight | 193.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoroethyl Standards
- Methyl 2-[1-(2,2-difluoroethyl)azetidin-3-yl]acetate (CAS 1432678-05-1)
- 4-(2,2-Difluoroethyl)piperidine-4-carboxylic acid (CAS 1503725-95-8)
- 1-(2,2-Difluoroethyl)piperidine-3-carboxylic acid (CAS 937602-80-7)
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- 4-(1,1-Difluoroethyl)thiazole-2-carboxylic acid (CAS 1780878-51-4)
- 3-(1,1-difluoroethyl)-1-methyl-1H-pyrazole-5-carboxylic acid (CAS 1024599-54-9)
- 1-(1,1-Difluoroethyl)naphthalene (CAS 1204295-97-5)
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Recommended Standards
- 3-(4,4-Difluoropiperidin-1-yl)propanoic acid (CAS 1204295-05-5)
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- tert-butyl N-(2,2-difluorocyclopropyl)carbamate (CAS 1163790-91-7)
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- 853767-19-8 3,4,5-Trifluoro-N-methylaniline MFCD11655741 (CAS 853767-19-8)
- 1,3,6-Trimethylpyrrolo[1,2-a]pyrazine (CAS 147674-37-1)
- (R)-N-Methyl-1-(5-(trifluoromethyl)pyrazin-2-yl)ethan-1-amine (CAS 2774613-10-2)
- Isopropyl 5-isopropoxynicotinate (CAS 1394953-96-8)
- (6-Methoxy-4-(trifluoromethyl)pyridin-3-yl)methanamine (CAS 1256791-10-2)
- (4-Amino-2-((4-chlorophenyl)amino)thiazol-5-yl)(3-nitrophenyl)methanone (CAS 339020-37-0)
- 3-(Benzyloxy)-5-fluorobenzoic acid (CAS 186584-74-7)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
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