Escitalopram Impurity 60 CAS 1219803-58-3
| CAS No. | 1219803-58-3 |
| Molecular Formula | - |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Escitalopram Impurity 60 (CAS 1219803-58-3, C20H17D4FN2OHBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, Escitalopram Impurity 60 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 409.33 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Escitalopram Impurity 60 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H17D4FN2O HBr |
| Molecular Weight | 409.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Escitalopram Standards
- Escitalopram Impurity 2 (CAS 103146-25-4)
- Escitalopram EP Impurity L Oxalate (CAS 1093072-86-6)
- Escitalopram USP Related Compound A (CAS 128173-53-5)
- Escitalopram EP Impurity K (CAS 128196-02-1)
- EsCitalopram EP Impurity I (CAS 1370643-22-3)
- Escitalopram EP Impurity M (CAS 1881237-26-8)
- Escitalopram EP Impurity F (CAS 2102609-59-4)
- Escitalopram EP Impurity K Oxalate (CAS 219861-53-7)
Recommended Standards
- Noscapine impurity 3 (CAS 82-54-2)
- Lubiprostone Impurity 33 (CAS CATO-C4X-113633)
- Suzetrigine Impurity 39 (CAS CATO-C4X-336939)
- (E)-4-bromo-2-(((3,5-dichlorophenyl)imino)methyl)phenol (CAS 303759-09-3)
- (S)-3,4-Dimethoxy-alpha-methylbenzylamine (CAS 65451-89-0)
- Favipiravir Impurity 11 (CAS 6863-74-7)
- 4-Cyclopropoxy-2-fluoro-N-methylaniline (CAS 1243375-76-9)
- 1,3,3,7-Tetramethylindolin-2-one (CAS 344287-38-3)
- 5-Methyl-5-(4-nitrophenyl)imidazolidine-2,4-dione (CAS 64464-22-8)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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