Escitalopram EP Impurity K Oxalate CAS 219861-53-7
| CAS No. | 219861-53-7 |
| Molecular Formula | C20H21FN2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Escitalopram EP Impurity K Oxalate.
As a process- or degradation-related impurity, Escitalopram EP Impurity K Oxalate (CAS 219861-53-7, C20H21FN2OC2H2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Escitalopram EP Impurity K Oxalate (C20H21FN2OC2H2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 414.43 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21FN2O C2H2O4 |
| Molecular Weight | 414.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Escitalopram Standards
- Escitalopram Impurity 2 (CAS 103146-25-4)
- Escitalopram EP Impurity L Oxalate (CAS 1093072-86-6)
- Escitalopram Impurity 60 (CAS 1219803-58-3)
- Escitalopram USP Related Compound A (CAS 128173-53-5)
- Escitalopram EP Impurity K (CAS 128196-02-1)
- EsCitalopram EP Impurity I (CAS 1370643-22-3)
- Escitalopram EP Impurity M (CAS 1881237-26-8)
- Escitalopram EP Impurity F (CAS 2102609-59-4)
Recommended Standards
- Trilaciclib Impurity 2 (CAS CATO-C4X-30442)
- Erlotinib Impurity 46 (CAS CATO-C4X-106946)
- Aprepitant Impurity 13 (CAS 183664-56-4)
- Methyl 6-amino-3-chloro-2-fluorobenzoate (CAS 2091850-02-9)
- 2-Naphthylmethylphosphonic acid (CAS 16672-84-7)
- BD140 [for Albumin binding assay] (CAS 1201643-08-4)
- Cephradine (1102805) (CAS 58456-86-3)
- Solriamfetol Impurity 5 (CAS CATO-C4X-25635)
- Butopamine HCl ((R,R)-Ractopamine HCl) (CAS 74432-68-1)
- Hexapeptide-1 (CAS CATO-CPTD788821)
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