Rosuvastatin Impurity 107 CAS 122549-26-2
| CAS No. | 122549-26-2 |
| Molecular Formula | C14H15FO3 |
| Molecular Weight | 250.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rosuvastatin Impurity 107 (CAS 122549-26-2, C14H15FO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Rosuvastatin Impurity 107 (C14H15FO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rosuvastatin Impurity 107 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H15FO3 |
| Molecular Weight | 250.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 27 (CAS 1044518-75-3)
- Rosuvastatin Impurity 29 (CAS CATO-C4X-116929)
- Rosuvastatin Impurity 30 (CAS CATO-C4X-116930)
- Rosuvastatin Impurity 61 (CAS 124752-23-4)
- Rosuvastatin Impurity 71 (CAS CATO-C4X-116971)
- Rosuvastatin Impurity 146 (CAS 148809-28-3)
- Rosuvastatin Impurity 64 (CAS 124655-09-0)
- Rosuvastatin Impurity 74 (CAS 407577-54-2)
Recommended Standards
- Atorvastatin impurity 163 (CAS 131000-98-1)
- Glutathione EP Impurity D (CAS 636-58-8)
- 947179-19-3 Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (CAS 947179-19-3)
- Acetylcysteine impurity 69 (CAS CATO-C4X-153269)
- Dexamethasone impurity 89 (CAS CATO-C4X-116589)
- Aclidinium bromide Impurity 4 (CAS 28569-88-2)
- Afatinib Impurity 4 (CAS CATO-C4X-10064)
- Avibactam Impurity 89 (CAS 1171080-45-7)
- Ethyl 2-((tert-butoxycarbonyl)((1-(hydroxymethyl)cyclopropyl)methyl)amino)acetate (CAS 1998216-45-7)
- (4-Benzhydrylpiperazin-1-yl)(2-(methylthio)pyridin-3-yl)methanone (CAS 852851-09-3)
- 3-(4-Chlorophenyl)-5,6-dimethyl-2-sulfanylthieno[2,3-d]pyrimidin-4(3h)-one (CAS 126105-97-3)
- 6-[(4-Bromophenyl)sulfanyl]-4-chloro-3-phenylpyridazine (CAS 477872-30-3)
- 2-(3-Aminophenyl)-2-azaspiro[4.4]nonane-1,3-dione (CAS 1154571-03-5)
- Semaglutide impurity 50 (CAS 2773558-66-8)
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