Pazopanib Impurity 5 CAS 1226499-97-3
| CAS No. | 1226499-97-3 |
| Molecular Formula | C13H12ClN5 |
| Molecular Weight | 273.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Pazopanib Impurity 5 (C13H12ClN5) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Pazopanib Impurity 5 (CAS 1226499-97-3), a pharmacopoeial impurity reference standard (molecular formula C13H12ClN5, MW 273.72 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pazopanib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12ClN5 |
| Molecular Weight | 273.72 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Pazopanib Standards
- Pazopanib Impurity 24 (CAS 444731-74-2)
- Pazopanib Impurity 63 (CAS 2369664-23-1)
- Pazopanib Impurity 13 (CAS CATO-C4X-172513)
- Pazopanib Impurity 47 (CAS 1821666-71-0)
- Pazopanib Impurity 8 (CAS 1296888-47-5)
- Pazopanib Impurity (CAS 1252927-45-9)
- Pazopanib USP Related Compound A (CAS 444731-75-3)
- Pazopanib Impurity 57 (CAS 444731-66-2)
Recommended Standards
- Alprazolam Impurity 4 (CAS 27610-14-6)
- Clofenamide-d3 (CAS 1794816-92-4)
- Sunitinib Impurity 89 (CAS CATO-C4X-133389)
- tert-Butyl N-(4-chloro-3-fluorophenyl)-N-ethylcarbamate (CAS 1881289-32-2)
- Bicalutamide Impurity 5 (CAS 1166228-30-3)
- Edoxaban Impurity 38 (CAS 1255529-24-8)
- Mirogabalin Impurity 62 (CAS 2767341-19-3)
- 8-Ethoxyquinolin-5-ol (CAS 856083-19-7)
- (S)-2-Amino-N-(thiophen-3-ylmethyl)propanamide (CAS 1344950-30-6)
- 1-(5-Bromo-4-methyl-2-pyridinyl)azepane (CAS 1219967-47-1)
- 5-Methoxy-4-[(4-methoxybenzyl)oxy]-2-nitrobenzoic Acid (CAS 1643979-88-7)
- 4-(3,5-Bis(trifluoromethyl)benzyl)piperidinehydrochloride (CAS 782504-63-6)
- N-(4-Hydroxyphenyl)cinnamamide (CAS 3579-85-9)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com