Pazopanib USP Related Compound A CAS 444731-75-3
| CAS No. | 444731-75-3 |
| Molecular Formula | C14H14ClN5 |
| Molecular Weight | 287.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pazopanib USP Related Compound A.
Pazopanib USP Related Compound A (CAS 444731-75-3), molecular formula C14H14ClN5 and molecular weight 287.75 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C14H14ClN5, Pazopanib USP Related Compound A contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 287.75 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14ClN5 |
| Molecular Weight | 287.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Pazopanib Standards
- Pazopanib Impurity (CAS 1252927-45-9)
- Pazopanib Impurity 8 (CAS 1296888-47-5)
- Pazopanib Impurity 15 (CAS 1379982-43-0)
- Pazopanib Impurity 24 (CAS 444731-74-2)
- Pazopanib Impurity 5 (CAS 1226499-97-3)
- Pazopanib Impurity 63 (CAS 2369664-23-1)
- Pazopanib Impurity 13 (CAS CATO-C4X-172513)
- Pazopanib Impurity 47 (CAS 1821666-71-0)
Recommended Standards
- Ethyl 2-((4-(tert-butylamino)-6-chloro-1,3,5-triazin-2-yl)amino)acetate (CAS 94628-61-2)
- 4-(2-(2-Oxopyrrolidin-1-yl)ethyl)benzenesulfonyl chloride (CAS 1017140-97-4)
- 6-(4-Chlorobenzyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (CAS 885949-37-1)
- 2-(5-Chloro-2-ethoxy-phenyl)-thiazolidine-4-carboxylic acid (CAS 1033301-31-3)
- 3-(3-Aminooxetan-3-yl)prop-2-yn-1-ol (CAS 2386154-49-8)
- 5-chloro-3-methylpyrazin-2-amine (CAS 1001050-30-1)
- 2-Fluorobenzofuran (CAS 280551-95-3)
- N-(4-Bromo-2-(3-chlorobenzoyl)phenyl)acetamide (CAS 406161-72-6)
- Ethyl 3-(bromomethyl)thieno[3,2-b]thiophene-2-carboxylate (CAS 1118786-99-4)
- 3-(Morpholine-4-carbonyl)-1-(4-(trifluoromethyl)benzyl)pyridin-2(1H)-one (CAS 338782-23-3)
- 2,3-Dibromobicyclo[2.2.1]heptane (CAS 60154-53-2)
- Ethyl 3-formylcyclobutane-1-carboxylate (CAS 1456695-29-6)
- Cyclohexyl(imino)(methyl)-lambda6-sulfanone (CAS 1085526-16-4)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
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