Abemaciclib impurity 109 CAS CATO-C4X-2937109
| CAS No. | CATO-C4X-2937109 |
| Molecular Formula | C11H13BrN2O |
| Molecular Weight | 269.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Abemaciclib impurity 109 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Abemaciclib impurity 109 (CAS CATO-C4X-2937109, C11H13BrN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abemaciclib impurity 109 (C11H13BrN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H13BrN2O |
| Molecular Weight | 269.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity 185 (CAS 871258-57-0)
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib impurity 110 (CAS CATO-C4X-2937110)
- Abemaciclib Impurity 124 (CAS 2380322-35-8)
- Abemaciclib Impurity 127 (CAS 2922910-91-4)
- Abemaciclib Impurity 135 (CAS CATO-C4X-2937135)
- Abemaciclib Impurity 148 (CAS 1844847-62-6)
- Abemaciclib Impurity 128 (CAS CATO-C4X-2937128)
Recommended Standards
- Lasmiditan Impurity 13 (CAS CATO-C4X-247813)
- 2-Methylquinoline-6-boronic acid pinacol ester, 97% (CAS 1022090-86-3)
- Cyclophosphamide-d8 (CAS 1178903-96-2)
- N-(2-aminoethyl)-2,3-dichlorobenzene-1-sulfonamide (CAS 1154979-05-1)
- Tenoxicam EP Impurity F (CAS CATO-C4X-23834)
- Lotilaner Impurity 25 (CAS 1613733-75-7)
- Abemaciclib Impurity 129 (CAS CATO-C4X-2937129)
- 4-(3,4-Difluorophenyl)butanoic acid (CAS 136295-00-6)
- 3-[3-(3-chlorophenyl)-1-(2-cyanoethyl)-1h-pyrazol-4-yl]-2-cyanoprop-2-enoic acid (CAS 1006442-26-7)
- 3-(Benzyloxy)-5-(iodomethyl)isoxazole (CAS 1428233-97-9)
- 3-Ethynyl-6-methyl-pyridazine (CAS 77778-20-2)
- 4-(Aminomethyl)-3-(difluoromethyl)-6-(trifluoromethyl)pyridin-2-ol (CAS 1805541-65-4)
- 6-(5-Methylthiophen-2-yl)-1-(propan-2-yl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 924232-60-0)
- Peptide YY (3-36) (human) (CAS 123583-37-9)
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