Abemaciclib Impurity 135 CAS CATO-C4X-2937135
| CAS No. | CATO-C4X-2937135 |
| Molecular Formula | C11H12BrFN2 |
| Molecular Weight | 271.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C11H12BrFN2, Abemaciclib Impurity 135 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 271.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Abemaciclib Impurity 135 (CAS CATO-C4X-2937135) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12BrFN2 and a molecular weight of 271.13 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12BrFN2 |
| Molecular Weight | 271.13 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib impurity 110 (CAS CATO-C4X-2937110)
- Abemaciclib Impurity 124 (CAS 2380322-35-8)
- Abemaciclib Impurity 127 (CAS 2922910-91-4)
- Abemaciclib Impurity 148 (CAS 1844847-62-6)
- Abemaciclib impurity 109 (CAS CATO-C4X-2937109)
- Abemaciclib Impurity 185 (CAS 871258-57-0)
- Abemaciclib Impurity 128 (CAS CATO-C4X-2937128)
Recommended Standards
- (3-(n-(Tert-butyl)-n-methylsulfamoyl)phenyl)boronic acid (CAS 1217501-22-8)
- (4-(N,N-Diethylsulfamoyl)-2-methylphenyl)boronic acid (CAS 1217501-54-6)
- 898791-68-9 (4-Bromo-2-fluorophenyl)(cyclopentyl)methanone DTXSID90642574 (CAS 898791-68-9)
- 3-Difluoromethoxy-6-(trifluoromethyl)pyridine-2-acetic acid (CAS 1227561-57-0)
- N-Nitroso Nafamostat impurity 93 (CAS CATO-C4X-133293)
- Dapagliflozin Impurity 106 (CAS CATO-C4X-1138106)
- Pemafibrate Impurity 13 (CAS CATO-C4X-290313)
- 3-Amino-4-ethoxy-N,N-dimethylbenzamide (CAS 1071290-49-7)
- (3-Ethoxy-4-methoxyphenyl)boronic acid (CAS 915201-13-7)
- Potassium (2-phenylacetyl)((trifluoro-lambda4-boranyl)methyl)amide (CAS 1253046-47-7)
- tert-butyl 3-(5-amino-1,3,4-oxadiazol-2-yl)pyrrolidine-1-carboxylate (CAS 1414958-41-0)
- 4-(3-Chlorophenyl)-1H-imidazole (CAS 912763-45-2)
- 2-(thietan-3-ylidene)acetic acid (CAS 1934863-13-4)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
Why CATO?
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