Abemaciclib Impurity 124 CAS 2380322-35-8
| CAS No. | 2380322-35-8 |
| Molecular Formula | C11H12BrFN2 |
| Molecular Weight | 271.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C11H12BrFN2, Abemaciclib Impurity 124 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 271.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Abemaciclib Impurity 124 (CAS 2380322-35-8) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12BrFN2 and a molecular weight of 271.13 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12BrFN2 |
| Molecular Weight | 271.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib impurity 110 (CAS CATO-C4X-2937110)
- Abemaciclib Impurity 127 (CAS 2922910-91-4)
- Abemaciclib Impurity 135 (CAS CATO-C4X-2937135)
- Abemaciclib Impurity 148 (CAS 1844847-62-6)
- Abemaciclib impurity 109 (CAS CATO-C4X-2937109)
- Abemaciclib Impurity 185 (CAS 871258-57-0)
- Abemaciclib Impurity 128 (CAS CATO-C4X-2937128)
Recommended Standards
- 898791-68-9 (4-Bromo-2-fluorophenyl)(cyclopentyl)methanone DTXSID90642574 (CAS 898791-68-9)
- N-(benzo[d]thiazol-6-yl)-2-bromoacetamide (CAS 916791-25-8)
- N-(4-Bromobenzo[d]thiazol-2-yl)acetamide (CAS 892852-97-0)
- (3-(n-(Tert-butyl)-n-methylsulfamoyl)phenyl)boronic acid (CAS 1217501-22-8)
- Anamorelin Impurity 15 (CAS CATO-C4X-285915)
- Selexipag Impurity 22 (CAS 2068134-98-3)
- Sitafloxacin impurity 53 (CAS 1933694-45-1)
- 3-Chloro-6-(1H-pyrrol-1-yl)pyridazine (CAS 5096-76-4)
- N-(Isothiazol-3-ylmethyl)ethanamine (CAS 952195-17-4)
- Ethyl 4-(5-cyanofuran-2-yl)benzoate (CAS 57666-76-9)
- (2-(Benzyloxy)-4-ethyl-6-methylpyridin-3-yl)methanol (CAS 1616288-84-6)
- (E)-Cyclooct-4-enol 85081-69-2 AK687187 (CAS 85081-69-2)
- CAS 958763-89-8 (CAS 958763-89-8)
- Neuropeptide S (human) (CAS 412938-67-1)
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