Imatinib Mesilate EP Impurity A CAS 123367-26-0
| CAS No. | 123367-26-0 |
| Molecular Formula | C10H12N2O |
| Molecular Weight | 176.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Imatinib Mesilate EP Impurity A (CAS 123367-26-0), a pharmacopoeial impurity reference standard (molecular formula C10H12N2O, MW 176.22 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Imatinib Mesilate EP Impurity A is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 176.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C10H12N2O |
| Molecular Weight | 176.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 2 |
Related Imatinib Standards
- Imatinib EP Impurity A (CAS 55314-16-4)
- Imatinib Impurity 57 (CAS 581076-64-4)
- Imatinib Impurity 29 (CAS 21900-30-1)
- Imatinib Impurity 59 (CAS 796738-72-2)
- Imatinib Impurity 45 (CAS 152460-07-6)
- Imatinib Impurity 93 (CAS 870459-88-4)
- Imatinib Impurity 58 (CAS 125743-63-7)
- Imatinib Impurity 63 (CAS 99-94-5)
Recommended Standards
- 915921-55-0 2-(4-Methyl-1H-benzimidazol-2-yl)ethan-1-ol DTXSID80649178 (CAS 915921-55-0)
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- (Z)-Nilotinib Impurity 37 (CAS 75415-01-9)
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- 6-(Ethyl(phenyl)amino)-2-methylpyrimidin-4(3H)-one (CAS 133062-55-2)
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