(Z)-Nilotinib Impurity 37 CAS 75415-01-9
| CAS No. | 75415-01-9 |
| Molecular Formula | C10H12N2O |
| Molecular Weight | 176.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), (Z)-Nilotinib Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies (Z)-Nilotinib Impurity 37 (CAS 75415-01-9), a pharmacopoeial impurity reference standard (molecular formula C10H12N2O, MW 176.22 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of (Z)-Nilotinib Impurity 37 (C10H12N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H12N2O |
| Molecular Weight | 176.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 2 |
Related Z Standards
- Nilotinib Impurity 25 (CAS 41574-91-8)
- Nilotinib 2-Pyridinyl Impurity (CAS 66521-65-1)
- Nilotinib Impurity 17 (CAS 18595-17-0)
- Nilotinib EP Impurity B (CAS 18595-18-1)
- Nilotinib Impurity 50 (CAS CATO-C4X-125650)
- Nilotinib Impurity 51 (CAS CATO-C4X-125651)
- Nilotinib Impurity 40 (CAS 859026-97-4)
- Nilotinib Hydrochloride Monohydrate EP Impurity C (CAS 2458-12-0)
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