Avatrombopag Impurity 20 CAS 123971-45-9
| CAS No. | 123971-45-9 |
| Molecular Formula | C7H5ClN2S2 |
| Molecular Weight | 216.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Avatrombopag Impurity 20 is closely related to a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Avatrombopag Impurity 20 (CAS 123971-45-9) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5ClN2S2 and a molecular weight of 216.71 g/mol.
Structurally, Avatrombopag Impurity 20 (C7H5ClN2S2) contains a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 216.71 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClN2S2 |
| Molecular Weight | 216.71 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 26 (CAS 339114-12-4)
- Avatrombopag Impurity 39 (CAS 570407-10-2)
- Avatrombopag Impurity 81 (CAS 401566-69-6)
- Avatrombopag Impurity N2 (CAS 54127-29-6)
- Avatrombopag Impurity 69 (CAS 91695-59-9)
- Avatrombopag Impurity 31 (CAS 69422-72-6)
- Avatrombopag Impurity 143 (CAS 2115508-48-8)
- Avatrombopag Impurity 51 (CAS CATO-C4X-223451)
Recommended Standards
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- 598298-10-3 4-Chloro-2-(methylsulfanyl)thieno[2,3-d]pyrimidine DTXSID20621236 (CAS 598298-10-3)
- 2-((2-Chloroethyl)sulfinyl)-1,4-dimethylbenzene (CAS 1170931-98-2)
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- 1-Benzyl-5-thioxopyrrolidin-2-one (CAS 95141-59-6)
- (R)-2-(3,4-dichlorophenyl)-2-(methylamino)ethan-1-ol (CAS 1335596-00-3)
- 4-Bromo-2H-benzo[h]chromen-2-one (CAS 2097816-01-6)
- 3-(7-methoxynaphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carboxylic acid (CAS 1208697-01-1)
- 4-(Prop-2-yn-1-yl)piperidine hydrochloride (CAS 2172188-51-9)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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