Avatrombopag Impurity 81 CAS 401566-69-6
| CAS No. | 401566-69-6 |
| Molecular Formula | C8H7Cl2NO2 |
| Molecular Weight | 220.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Avatrombopag Impurity 81 (CAS 401566-69-6) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7Cl2NO2 and a molecular weight of 220.05 g/mol.
Based on its molecular formula C8H7Cl2NO2, Avatrombopag Impurity 81 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 220.05 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Avatrombopag Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7Cl2NO2 |
| Molecular Weight | 220.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Avatrombopag Standards
- Avatrombopag Impurity 26 (CAS 339114-12-4)
- Avatrombopag Impurity 20 (CAS 123971-45-9)
- Avatrombopag Impurity 39 (CAS 570407-10-2)
- Avatrombopag Impurity 31 (CAS 69422-72-6)
- Avatrombopag Impurity N2 (CAS 54127-29-6)
- Avatrombopag Impurity 69 (CAS 91695-59-9)
- Avatrombopag Impurity 51 (CAS CATO-C4X-223451)
- Avatrombopag Impurity 95 (CAS CATO-C4X-223495)
Recommended Standards
- Bosutinib Impurity 26 (CAS 67669-19-6)
- Resmetirom impurity 53 (CAS 79694-26-1)
- Methyl 5-amino-2,4-dichlorobenzoate (CAS 84228-48-8)
- Resmetirom impurity 54 (CAS 62918-73-4)
- Belumosudil Impurity 69 (CAS CATO-C4X-298869)
- Ceftolozane Impurity 31 (CAS CATO-C4X-240631)
- Edaravone impurity 48 (CAS 87343-64-4)
- 1-(4-Methylphenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline (CAS 343372-45-2)
- 1,4-dimethylpiperidine-4-carboxylic acid (CAS 162648-33-1)
- 4-(4-Aminophenyl)-2,6-bis(4-aminophenyl)pyridine (CAS 83266-97-1)
- 3,5-Diphenylpyridine (CAS 92-07-9)
- 4-(2-Methylcyclohexyl)-5-(m-tolyl)-4H-1,2,4-triazole-3-thiol (CAS 565169-48-4)
- Dopamine Impurity 31 (CAS 3213-28-3)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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