Avatrombopag Impurity 143 CAS 2115508-48-8
| CAS No. | 2115508-48-8 |
| Molecular Formula | C8H8ClNO3 |
| Molecular Weight | 201.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Avatrombopag Impurity 143 (CAS 2115508-48-8, C8H8ClNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H8ClNO3, Avatrombopag Impurity 143 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 201.61 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Avatrombopag Impurity 143 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO3 |
| Molecular Weight | 201.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Avatrombopag Standards
- Avatrombopag Impurity 91 (CAS CATO-C4X-223491)
- Avatrombopag Impurity 68 (CAS 2325305-38-0)
- Avatrombopag Impurity 69 (CAS 91695-59-9)
- Avatrombopag Impurity N2 (CAS 54127-29-6)
- Avatrombopag Impurity 30 (CAS 73027-79-9)
- Avatrombopag Impurity 43 (CAS 38496-18-3)
- Avatrombopag Impurity 32 (CAS 41667-95-2)
- Avatrombopag Impurity 85 (CAS 677762-31-1)
Recommended Standards
- Phenacetin Impurity 5 (CAS 102236-24-8)
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- Apixaban Impurity 6 (CAS 1074365-84-6)
- Apremilast Impurity 35 (CAS CATO-C4X-100935)
- Eribulin Impurity 6 (CAS CATO-C4X-26506)
- 3-(4-Methoxyphenyl)pentan-3-ol (CAS 17138-75-9)
- 8-Bromo-11H-benzo[a]carbazole (CAS 21064-34-6)
- 6-Cyclopropyl-n2,n2-diethyl-1,3,5-triazine-2,4-diamine (CAS 1340107-93-8)
- 6-Amino-1-naphthaldehyde (CAS 1261529-65-0)
- 1-Methyl-3-(((2-methylbenzyl)oxy)methyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (CAS 1306738-40-8)
- 4H,5H-pyrrolo[1,2-a]quinoxalin-4-one (CAS 6025-68-9)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
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