Capmatinib Impurity 4 CAS 1243392-80-4
| CAS No. | 1243392-80-4 |
| Molecular Formula | C8H8FNO2 |
| Molecular Weight | 169.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Capmatinib Impurity 4 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Capmatinib Impurity 4 (CAS 1243392-80-4) is a certified pharmaceutical impurity reference standard with the molecular formula C8H8FNO2 and a molecular weight of 169.15 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Capmatinib Impurity 4 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 169.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8FNO2 |
| Molecular Weight | 169.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Capmatinib Standards
- Capmatinib Impurity 9 (CAS CATO-C4X-29859)
- Capmatinib Impurity 3 (CAS CATO-C4X-29853)
- Capmatinib Dihydrochloride (CAS 1197376-85-4)
- Capmatinib M18 Metabolite (CAS 1029713-99-2)
- Capmatinib Impurity 5 (CAS 1029714-88-2)
- Capmatinib (CAS 1029712-80-8)
- Capmatinib Impurity 7 (CAS CATO-C4X-29857)
- Capmatinib Impurity 6 (CAS CATO-C4X-29856)
Recommended Standards
- Regorafenib Impurity 58 (CAS 103842-00-8)
- 2H-Thieno[2,3-d][1,3]oxazine-2,4(1H)-dione (CAS 103979-54-0)
- Enzalutamide Impurity 19 (CAS 73792-08-2)
- 1H-Thieno[2,3-d][1,2,3]triazole-5-carboxylic acid (CAS 107166-05-2)
- Relebactam Impurity 11 (CAS CATO-C4X-214411)
- Efinaconazole Impurity 14 (CAS 135270-10-9)
- Methylene blue Impurity 8 (CAS 2204245-78-1)
- 4-Bromo-5-isopropoxybenzene-1,2-diamine (CAS 1373232-64-4)
- N-(benzo[d]thiazol-2-yl)pyrrolidine-2-carboxamide (CAS 1078791-18-0)
- Methyl 2-methyl-4-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (CAS 130734-38-2)
- Phenyl (1-(furan-2-yl)propan-2-yl)carbamate (CAS 1235617-86-3)
- 3-Phenyl-1,4-diazaspiro[4.5]Dec-3-ene-2-thione (CAS 4602-36-2)
- (E)-Dec-2-en-1-yl acetate (CAS 2497-23-6)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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