Capmatinib Impurity 3 CAS CATO-C4X-29853
| CAS No. | CATO-C4X-29853 |
| Molecular Formula | C16H14F2N2O2 |
| Molecular Weight | 304.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Capmatinib Impurity 3 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Capmatinib Impurity 3 (CAS CATO-C4X-29853), a pharmacopoeial impurity reference standard (molecular formula C16H14F2N2O2, MW 304.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Capmatinib Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 304.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Capmatinib Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H14F2N2O2 |
| Molecular Weight | 304.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Capmatinib Standards
- Capmatinib Impurity 9 (CAS CATO-C4X-29859)
- Capmatinib M18 Metabolite (CAS 1029713-99-2)
- Capmatinib Impurity 5 (CAS 1029714-88-2)
- Capmatinib (CAS 1029712-80-8)
- Capmatinib Impurity 4 (CAS 1243392-80-4)
- Capmatinib Impurity 7 (CAS CATO-C4X-29857)
- Capmatinib Impurity 6 (CAS CATO-C4X-29856)
- Capmatinib Dihydrochloride (CAS 1197376-85-4)
Recommended Standards
- Abemaciclib Impurity 20 (CAS CATO-C4X-293720)
- Lemborexant Impurity 44 (CAS CATO-C4X-304244)
- 2855-92-7 4,6-Dimethoxy-2'-methyl-3,4',6'-grisantrione (CAS 2855-92-7)
- 3-(3-Hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (CAS 35400-60-3)
- Indobufen Impurity 87 (CAS CATO-C4X-179287)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
- Empagliflozin Impurity 105 (CAS 915095-90-8)
- (3S,5R)-5-amino-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (CAS 2306254-44-2)
- H-Orn(Boc)-OH (CAS 13650-49-2)
- 4-((3-(Benzyloxy)benzylidene)amino)-3-(2-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 676537-60-3)
- (3-(((Tert-butoxycarbonyl)amino)methyl)oxetan-3-yl)-L-valine (CAS 2209833-33-8)
- 7-Fluoro-8-methylquinoline (CAS 1260899-31-7)
- Tl in water quality (CAS CATO-CQCM102203)
- D-[Thr]7-Liraglutide (CAS CATO-C4X-199237)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com