Tenofovir disoproxil Impurity 18 CAS 1244022-53-4
| CAS No. | 1244022-53-4 |
| Molecular Formula | C20H32N5O11P |
| Molecular Weight | 549.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C20H32N5O11P, Tenofovir disoproxil Impurity 18 contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 549.47 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Tenofovir disoproxil Impurity 18 (CAS 1244022-53-4) is a certified pharmaceutical impurity reference standard with the molecular formula C20H32N5O11P and a molecular weight of 549.47 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H32N5O11P |
| Molecular Weight | 549.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- Tenofovir disoproxil Impurity 111 (CAS 1607007-18-0)
- Tenofovir disoproxil Impurity 138 (CAS CATO-C4X-1076138)
- Tenofovir disoproxil Impurity 126 (CAS CATO-C4X-1076126)
- Tenofovir exalidex, 98% (CAS 911208-73-6)
- Tenofovir alafenamide63 (CAS CATO-C4X-179763)
- Tenofovir disoproxil Impurity 139 (CAS CATO-C4X-1076139)
- Tenofovir Disoproxil (S)-Isomer (CAS 1280130-08-6)
- Tenofovir disoproxil (CAS 201341-05-1)
Recommended Standards
- Methyl 2-(4-(2,4-dichlorophenoxy)butanamido)-5-((2,4-dimethylphenyl)carbamoyl)-4-methylthiophene-3-carboxylate (CAS 505095-55-6)
- Cangrelor Impurity N1 (CAS 847460-53-1)
- (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylamino)phenyl)-2-(2-bromo-3-oxospiro[3.5]non-1-en-1-ylamino)propanoate (CAS 455264-30-9)
- Deferasirox acyl-β-D-glucuronide (CAS 1233196-91-2)
- Cefepime EP Impurity D Potassium Salt (CAS 112097-97-9)
- Nitroso Perindopril EP impurity W (CAS CATO-C4X-125260)
- Tulobuterol Impurity 22 (CAS 5639-00-9)
- Entrectinib Impurity 1 (CAS CATO-C4X-29051)
- {6-Methylimidazo[1,2-a]pyridin-8-yl}boronic acid (CAS 2377607-68-4)
- (1R,2R)-2-(4-(benzyloxy)phenyl)cyclopropane-1-carboxylic acid (CAS 1257122-75-0)
- Fmoc-Tyr(Bzl)-OH (CAS 71989-40-7)
- 2-Amino-N-(((S)-1-benzylpiperidin-2-yl)methyl)-3-methylbutanamide (CAS 1354026-58-6)
- Ethyl 2-(tert-Butyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate (CAS 827014-34-6)
- Tirzepatide Impurity 34 (CAS CATO-C4X-324034)
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