Tenofovir disoproxil Impurity 14 CAS 1244022-56-7(Free Base)
| CAS No. | 1244022-56-7(Free Base) |
| Molecular Formula | C18H28N5O9P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tenofovir disoproxil Impurity 14 is closely related to a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Tenofovir disoproxil Impurity 14 (CAS 1244022-56-7(Free Base)) is a certified pharmaceutical impurity reference standard with the molecular formula C18H28N5O9PC4H4O4 and a molecular weight of 605.49 g/mol.
Tenofovir disoproxil Impurity 14 (C18H28N5O9PC4H4O4) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H28N5O9P C4H4O4 |
| Molecular Weight | 605.49 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 79 (CAS 102-10-3)
- rac Tenofovir-d6 (CAS 1020719-94-1)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir Disoproxil Dimer (CAS 1093279-76-5)
- Tenofovir disoproxil Impurity 6 (CAS 1093279-77-6)
- Tenofovir disoproxil Impurity 28 (CAS 1115-59-9)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
Recommended Standards
- N-Nitroso Thiamazole EP Impurity A (CAS 111348-65-3)
- Entecavir Impurity 25 (CAS 110567-22-1)
- Lafutidine Impurity 2 (CAS 174583-84-7)
- Venetoclax Impurity 10 (CAS CATO-C4X-249510)
- 2-(2-Aminobutan-2-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one hydrochloride (CAS 1333729-35-3)
- 1,3-Didodecyl-2-methyl-1H-imidazol-3-ium chloride (CAS 21054-71-7)
- Ethyl 3-amino-4,4,4-trifluorobutanoate hydrochloride (CAS 146425-31-2)
- Benzene, 2-(difluoromethoxy)-1,4-dimethyl- (CAS 1226388-16-4)
- 4-[di(methyl-d3)amino]benzoic acid (CAS 1175002-09-1)
- Liraglutide Impurity 31 (CAS CATO-C4X-199231)
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