Losartan Impurity 14 CAS 124750-92-1
| CAS No. | 124750-92-1 |
| Molecular Formula | C22H21ClN6O2 |
| Molecular Weight | 436.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Losartan Impurity 14 (CAS 124750-92-1, C22H21ClN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Losartan Impurity 14 (C22H21ClN6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H21ClN6O2 |
| Molecular Weight | 436.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Losartan Standards
- Losartan Impurity 44 (CAS CATO-C4X-168344)
- Losartan Impurity 19 (CAS 114798-94-6)
- Losartan impurity 31 (CAS CATO-C4X-168331)
- Losartan Impurity 53 (CAS 2904682-23-9)
- Losartan Impurity 54 (CAS 2904682-22-8)
- Losartan-d3 Carboxylic Acid (CAS 1189729-40-5)
- Losartan Carboxylic Acid-d4 (CAS 1246820-62-1)
- Losartan Impurity 50 (CAS CATO-C4X-168350)
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