Losartan Impurity 28 CAS 124750-67-0
| CAS No. | 124750-67-0 |
| Molecular Formula | C22H20ClN3O |
| Molecular Weight | 377.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 377.87 g/mol gives Losartan Impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Losartan Impurity 28 (CAS 124750-67-0, C22H20ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Losartan Impurity 28 (C22H20ClN3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Losartan Impurity 28 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H20ClN3O |
| Molecular Weight | 377.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Losartan Standards
- Losartan Impurity 57 (CAS C4X-13305)
- Losartan Impurity 61 (CAS CATO-C4X-168361)
- Losartan Impurity 15 (CAS 114772-55-3)
- Losartan Impurity 29 (CAS 2204369-11-7)
- Losartan Impurity 51 (CAS CATO-C4X-168351)
- Losartan Impurity N2 (CAS 1351793-76-4)
- Losartan Impurity 37 (CAS CATO-C4X-168337)
- Losartan Impurity 49 (CAS CATO-C4X-168349)
Recommended Standards
- Tert-butyl 3-(((3-chloroquinoxalin-2-yl)oxy)methyl)piperidine-1-carboxylate (CAS 939986-43-3)
- 4-[(E)-[(Thiophen-2-yl)methylidene]amino]phenyl 4-chlorobenzene-1-sulfonate (CAS 328287-38-3)
- CMC2026 Impurity 6 (CAS CATO-C4X-22666)
- 2-Chloro-N,N-diethyl-6,7-diphenylimidazo[1,2-b][1,2,4]triazin-3-amine (CAS 90170-13-1)
- Crizotinib impurity 16 (CAS 877397-65-4)
- Atogepant Impurity 75 (CAS CATO-C4X-328575)
- Olmesartan impurity C (CAS CATO-C4X-10973)
- Tert-butyl 4-(1,4-dioxa-8-azaspiro[4.5]Decan-8-yl)piperidine-1-carboxylate (CAS 579500-29-1)
- 1-(4-Methyl-1,3-thiazol-2-yl)cyclopentan-1-amine (CAS 1181234-20-7)
- 4-ethylcyclohexanecarbaldehyde (CAS 167545-47-3)
- (3E)-1,1,1-Trifluoro-4-{[2-(1H-indol-3-yl)ethyl]amino}but-3-en-2-one (CAS 478040-78-7)
- (E)-Cyclooct-2-en-1-yl (4-nitrophenyl) carbonate (CAS 1580501-97-8)
- Brivaracetam impurity 96 (CAS 164453-64-9)
- Semaglutide Impurity 146 (CAS 2645421-68-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com