Losartan Impurity 19 CAS 114798-94-6
| CAS No. | 114798-94-6 |
| Molecular Formula | C23H25ClN6O |
| Molecular Weight | 436.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Losartan Impurity 19 (CAS 114798-94-6, C23H25ClN6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Losartan Impurity 19 (C23H25ClN6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 436.94 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H25ClN6O |
| Molecular Weight | 436.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Losartan Standards
- Losartan impurity 31 (CAS CATO-C4X-168331)
- Losartan Impurity 14 (CAS 124750-92-1)
- Losartan Impurity 44 (CAS CATO-C4X-168344)
- Losartan Impurity 53 (CAS 2904682-23-9)
- Losartan Impurity 54 (CAS 2904682-22-8)
- Losartan-d3 Carboxylic Acid (CAS 1189729-40-5)
- Losartan Carboxylic Acid-d4 (CAS 1246820-62-1)
- Losartan Impurity 50 (CAS CATO-C4X-168350)
Recommended Standards
- 4-(3-Chlorophenyl)-5-[3-(morpholine-4-sulfonyl)phenyl]-4H-1,2,4-triazole-3-thiol (CAS 721418-75-3)
- 4-(2-Chloro-phenyl)-5-[3-(morpholine-4-sulfonyl)-phenyl]-4H-[1,2,4]triazole-3-thiol (CAS 748793-42-2)
- 2-Chloro-N-((3S,4S)-4-hydroxy-1-tosylpyrrolidin-3-yl)-N-((R)-1-phenylethyl)acetamide (CAS 1159908-19-6)
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- Lusutrombopag Impurity 16 (CAS CATO-C4X-208416)
- Cefazolin Impurity P5 (CAS CATO-C4X-157749)
- Selexipag Impurity 18 (CAS CATO-C4X-196118)
- Trifarotene Impurity 8 (CAS 895542-96-8)
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- 1-Pyrimidin-2-ylethanol (CAS 53342-30-6)
- (Methylsulfonyl)benzene- (CAS 125562-53-0)
- Semaglutide (CAS CATO-C4X-2226105)
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