Betamethasone Impurity 34(Mixture of Diastereomers) CAS 1249-19-0
| CAS No. | 1249-19-0 |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Betamethasone Impurity 34(Mixture of Diastereomers) (C22H29FO5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 392.46 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Betamethasone Impurity 34(Mixture of Diastereomers) (CAS 1249-19-0, C22H29FO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Impurity 22 (CAS 2990-65-0)
- Betamethasone EP Impurity H (CAS 185613-71-2)
- Betamethasone Impurity 117 (CAS CATO-C4X-1437117)
- Betamethasone Impurity 145 (CAS CATO-C4X-1437145)
- Betamethasone impurity 71 (CAS 37926-76-4)
- Betamethasone EP Impurity I (CAS 185613-69-8)
- Betamethasone impurity 97 (CAS 1150311-95-7)
- Betamethasone impurity 98 (CAS CATO-C4X-143798)
Recommended Standards
- Dexamethasone impurity 69 (CAS CATO-C4X-116569)
- Dexamethasone impurity 68 (CAS CATO-C4X-116568)
- Fluticasone Impurity 56 (CAS CATO-C4X-165056)
- Dexamethasone impurity 67 (CAS CATO-C4X-116567)
- Metoclopramide impurity 79 (CAS CATO-C4X-141579)
- Imrecoxib Impurity 68 (CAS CATO-C4X-237968)
- Siponimod impurity 33 (CAS CATO-C4X-247233)
- 3-((((1-(Difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)methyl)phenol hydrochloride (CAS 1855951-07-3)
- Alogliptin Impurity 35 (CAS CATO-C4X-109935)
- 4-Amino-5-chlorobenzo[c][1,2]oxaborol-1(3H)-ol (CAS 947165-31-3)
- 3-Acetamido-6-acetyl-2-nitrophenyl 4-(dimethylamino)-3,5-difluorobenzoate (CAS 1548406-25-2)
- n-(2-Aminoethyl)cyclopropanesulfonamide (CAS 1241911-78-3)
- 5-[3-Bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one (CAS 311795-38-7)
- D-Gln24-Tirzepatide (CAS CATO-CPTD788910)
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