Betamethasone EP Impurity I CAS 185613-69-8
| CAS No. | 185613-69-8 |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Betamethasone EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Betamethasone EP Impurity I (CAS 185613-69-8), a pharmacopoeial impurity reference standard (molecular formula C22H29FO5, MW 392.46 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C22H29FO5, Betamethasone EP Impurity I contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 392.46 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Impurity 22 (CAS 2990-65-0)
- Betamethasone EP Impurity H (CAS 185613-71-2)
- Betamethasone Impurity 117 (CAS CATO-C4X-1437117)
- Betamethasone Impurity 145 (CAS CATO-C4X-1437145)
- Betamethasone Impurity 34(Mixture of Diastereomers) (CAS 1249-19-0)
- Betamethasone impurity 71 (CAS 37926-76-4)
- Betamethasone impurity 97 (CAS 1150311-95-7)
- Betamethasone impurity 98 (CAS CATO-C4X-143798)
Recommended Standards
- Fluticasone Impurity 56 (CAS CATO-C4X-165056)
- Fluorometholone Impurity 8 (CAS CATO-C4X-19338)
- Betamethasone (CAS 378-44-9)
- Dexamethasone impurity 69 (CAS CATO-C4X-116569)
- Cefdinir Impurity 88 (CAS CATO-C4X-121088)
- Oseltamivir Impurity 47 (CAS 2081110-44-1（free base）)
- Diphenhydramin EP Impurity B HCl (Dimenhydrinate EP Impurity G HCl) (CAS 4024-34-4)
- 5-Bromo-4-chloro-6-methylpyridine-3-carboxylic acid (CAS 1394042-74-0)
- N,N’-Ditrityl Losartan a-Butyl-losartan Aldehyde Adduct (CAS 1797121-42-6)
- (2S)-5-chloroindoline-2-carboxylic acid (CAS 1344408-15-6)
- 2-Chloro-N-(1-phenylpropyl)propanamide (CAS 40023-47-0)
- Aluminum,hydroxy[1H-pyrazole-3,5-dicarboxylato(2-)-κO3]- (CAS 2261060-23-3)
- Ethyl 2-(tert-butyl)imidazo[2,1-b][1,3,4]thiadiazole-6-carboxylate (CAS 1092346-67-2)
- Semaglutide impurity 41 (CAS CATO-C4X-222641)
Why CATO?
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