Hydrocortisone Acetate EP Impurity F CAS 1250-97-1
| CAS No. | 1250-97-1 |
| Molecular Formula | C23H32O6 |
| Molecular Weight | 404.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Hydrocortisone Acetate EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Hydrocortisone Acetate EP Impurity F (CAS 1250-97-1, C23H32O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Hydrocortisone Acetate EP Impurity F (C23H32O6) contains a flavonoid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 404.50 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H32O6 |
| Molecular Weight | 404.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Hydrocortisone Standards
- Hydrocortisone EP Impurity J (CAS 16463-74-4)
- Hydrocortisone EP Impurity C (CAS 50-03-3)
- Hydrocortisone Impurity 30 (CAS CATO-C4X-140130)
- Hydrocortisone Impurity 51 (CAS CATO-C4X-140151)
- Hydrocortisone Impurity 69 (CAS 2905373-61-5)
- Hydrocortisone Impurity 36 (CAS 116846-74-3)
- Hydrocortisone 17-Propionate (CAS 65980-97-4)
- Hydrocortisone 21-Propionate (CAS 6677-98-1)
Recommended Standards
- Salbutamol Impurity 173 (CAS CATO-C4X-1176173)
- Irbesartan Impurity 22 (CAS CATO-C4X-166622)
- Edoxaban Impurity 73 (CAS 1057651-37-2)
- Gadoteridol Impurity 47 (CAS CATO-C4X-225747)
- Reboxetine Impurity 1 (CAS CATO-C4X-18701)
- Tetrabenazine Impurity 66 (CAS CATO-C4X-274866)
- Pomalidomide Impurity 48 (CAS CATO-C4X-135448)
- Pyrimidin-4(1H)-one 2-(2-amino-5-bromo-6-oxocyclohexa-1,3-dien-1-yl)acetate (CAS 138143-63-2)
- (E)-Sunitinib (CAS 1691223-83-2)
- 4-Cyclopropylbenzoyl Chloride (CAS 76274-94-7)
- 5-(4-Methylpiperidine-1-carboxamido)naphthalene-1-sulfonyl chloride (CAS 728864-80-0)
- 2-(4-(Phenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)acetic acid (CAS 1713476-47-1)
- 4-(Hydroxymethyl)-3-methylphenol (CAS 22574-58-9)
- Semaglutide impurity 272 (CAS CATO-C4X-2226272)
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