1-Chloro-3-(difluoromethoxy)-2,4-difluorobenzene CAS 1261769-13-4
| CAS No. | 1261769-13-4 |
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Chloro-3-(difluoromethoxy)-2,4-difluorobenzene.
1-Chloro-3-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261769-13-4) is a high-purity analytical reference standard with the molecular formula C7H3ClF4O and a molecular weight of 214.54 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 1-Chloro-3-(difluoromethoxy)-2,4-difluorobenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 214.54 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-4-fluoro-2-(trifluoromethoxy)benzene (CAS 114021-45-3)
- 2-Chloro-6-fluoro-4-(trifluoromethyl)phenol (CAS 116640-09-6)
- 1-[Chloro(difluoro)methoxy]-2,4-difluoro-benzene (CAS 123572-68-9)
- 2-Chloro-6-fluoro-3-(trifluoromethyl)phenol (CAS 1254781-50-4)
- 1-Chloro-5-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261808-36-9)
- 2-Chloro-5-(difluoromethoxy)-1,3-difluorobenzene (CAS 1261846-38-1)
- 2-Chloro-3-(difluoromethoxy)-1,4-difluoro-benzene (CAS 1261869-12-8)
- 1-Chloro-4-(difluoromethoxy)-2,5-difluorobenzene (CAS 1261884-44-9)
Recommended Standards
- 5-Chloro-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione (CAS 85730-40-1)
- 2-Chloro-1-fluoro-4-(trifluoromethoxy)benzene (CAS 128540-52-3)
- 3-Chloro-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 1322794-24-0)
- 1-[Chloro(difluoro)methoxy]-2,3-difluoro-benzene (CAS 1404193-57-2)
- 3-isopropyl-4,5-dimethylaniline (CAS 96155-99-6)
- 2-Chloro-6-(trifluoromethyl)benzaldehyde (CAS 60611-22-5)
- Methyl 2,5-dimethylnicotinate (CAS 63820-72-4)
- N-Methyl-2-nitroaniline-d3 (CAS 112333-14-9)
- N1-(3-Bromobenzyl)-N1-cyclopropylethane-1,2-diamine (CAS 1181753-32-1)
- 4-Chloro-1-hydroxy-2-naphthoic Acid (CAS 5409-15-4)
- 1-(4-(2-Methylthiazol-4-yl)phenyl)ethan-1-amine dihydrochloride (CAS 1049778-47-3)
- (1R,5R,6S)-2-azabicyclo[3.2.0]Heptan-6-ol hydrochloride (CAS 2095192-32-6)
- Methyl 2-((tert-butoxycarbonyl)(2-oxoethyl)amino)acetate (CAS 175211-73-1)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
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