1-Chloro-5-(difluoromethoxy)-2,4-difluorobenzene CAS 1261808-36-9
| CAS No. | 1261808-36-9 |
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Chloro-5-(difluoromethoxy)-2,4-difluorobenzene (C7H3ClF4O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 1-Chloro-5-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261808-36-9), a certified reference material (molecular formula C7H3ClF4O, MW 214.54 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-4-fluoro-2-(trifluoromethoxy)benzene (CAS 114021-45-3)
- 2-Chloro-6-fluoro-4-(trifluoromethyl)phenol (CAS 116640-09-6)
- 1-[Chloro(difluoro)methoxy]-2,4-difluoro-benzene (CAS 123572-68-9)
- 2-Chloro-6-fluoro-3-(trifluoromethyl)phenol (CAS 1254781-50-4)
- 1-Chloro-3-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261769-13-4)
- 2-Chloro-5-(difluoromethoxy)-1,3-difluorobenzene (CAS 1261846-38-1)
- 2-Chloro-3-(difluoromethoxy)-1,4-difluoro-benzene (CAS 1261869-12-8)
- 1-Chloro-4-(difluoromethoxy)-2,5-difluorobenzene (CAS 1261884-44-9)
Recommended Standards
- 2-Chloro-1-fluoro-4-(trifluoromethoxy)benzene (CAS 128540-52-3)
- 1-[Chloro(difluoro)methoxy]-2,3-difluoro-benzene (CAS 1404193-57-2)
- 5-Chloro-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione (CAS 85730-40-1)
- 1-Chloro-3-fluoro-2-(trifluoromethoxy)benzene (CAS 1404193-77-6)
- 2-Hydroxy-5-(2-hydroxy-4-methoxybenzyl)-4-methoxybenzaldehyde (CAS 953427-66-2)
- 5-Chloro-6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-ol (CAS 1379811-45-6)
- Boc-Dab-OtBu ยท HCl (CAS 190447-69-9)
- (4S)-3,4-Dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazin-4-ol 1,1-Dioxide (CAS 1029324-91-1)
- (4-chlorophenyl)(3-{[(2,4-dichlorophenyl)sulfanyl]methyl}-1-benzofuran-2-yl)methanone 338411-47-5 KS-000035U8 (CAS 338411-47-5)
- 1-Bromo-4-(2,2-difluorocyclopropyl)benzene (CAS 1275621-14-1)
- 4-amino-2-chloro-N-(pyridin-2-ylmethyl)benzamide (CAS 954574-19-7)
- (1-Cyclohexylvinyl)boronic acid (CAS 1202245-69-9)
- 3-((2-Methylfuran-3-yl)thio)heptan-4-one (CAS 61295-41-8)
- TRAF6 Peptide trifluoroacetate salt (CAS 852805-92-6)
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