2-Chloro-1-fluoro-4-(trifluoromethoxy)benzene CAS 128540-52-3
| CAS No. | 128540-52-3 |
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-1-fluoro-4-(trifluoromethoxy)benzene (CAS 128540-52-3), molecular formula C7H3ClF4O and molecular weight 214.54 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-1-fluoro-4-(trifluoromethoxy)benzene (C7H3ClF4O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-1-fluoro-4-(trifluoromethoxy)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-4-fluoro-2-(trifluoromethoxy)benzene (CAS 114021-45-3)
- 2-Chloro-6-fluoro-4-(trifluoromethyl)phenol (CAS 116640-09-6)
- 1-[Chloro(difluoro)methoxy]-2,4-difluoro-benzene (CAS 123572-68-9)
- 2-Chloro-6-fluoro-3-(trifluoromethyl)phenol (CAS 1254781-50-4)
- 1-Chloro-3-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261769-13-4)
- 1-Chloro-5-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261808-36-9)
- 2-Chloro-5-(difluoromethoxy)-1,3-difluorobenzene (CAS 1261846-38-1)
- 2-Chloro-3-(difluoromethoxy)-1,4-difluoro-benzene (CAS 1261869-12-8)
Recommended Standards
- 1-Chloro-4-(difluoromethoxy)-2,5-difluorobenzene (CAS 1261884-44-9)
- 1-[Chloro(difluoro)methoxy]-2,3-difluoro-benzene (CAS 1404193-57-2)
- 1-Chloro-3-fluoro-2-(trifluoromethoxy)benzene (CAS 1404193-77-6)
- 2-Chloro-4-fluoro-1-(trifluoromethoxy)benzene (CAS 1404194-16-6)
- Methyl 2-piperidinecarboxylate (CAS 41994-45-0)
- 4-Methoxybenzo[d]oxazol-2(3H)-one (CAS 40925-62-0)
- 1-(Benzyloxy)-4-ethynyl-2-methoxybenzene (CAS 144735-54-6)
- 3-Pentylzinc bromide 0.5 M in Tetrahydrofuran (CAS 308796-09-0)
- 2-(3,5-Dimethylpiperidin-1-yl)-2-phenylacetic acid (CAS 1105699-34-0)
- 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde compound with benzene-1,4-diamine (1:1) (CAS 1414350-37-0)
- 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-8-(tert-butoxycarbonyl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 849928-23-0)
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- 3-AminoiSoxazol-5-yl methyl hydrogen phosphate (CAS 189003-16-5)
- D-Lys16-Tirzepatide (CAS CATO-CPTD788918)
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