Lubiprostone Impurity 3 CAS 1263283-38-0
| CAS No. | 1263283-38-0 |
| Molecular Formula | C20H32F2O5 |
| Molecular Weight | 390.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 390.46 g/mol gives Lubiprostone Impurity 3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Lubiprostone Impurity 3 (CAS 1263283-38-0, C20H32F2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lubiprostone Impurity 3 (C20H32F2O5) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H32F2O5 |
| Molecular Weight | 390.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Lubiprostone Standards
- Lubiprostone (CAS 136790-76-6/333963-40-9)
- Lubiprostone Impurity 18 (CAS 201226-21-3)
- Lubiprostone Impurity 30 (CAS 2743427-14-5)
- Lubiprostone Impurity 31 (CAS CATO-C4X-113631)
- Lubiprostone Impurity 32 (CAS CATO-C4X-113632)
- Lubiprostone Impurity 33 (CAS CATO-C4X-113633)
- Lubiprostone Impurity 35 (CAS 1808535-45-6 (Cyclo Form))
- Lubiprostone Impurity 40 (CAS CATO-C4X-113640)
Recommended Standards
- Sildenafil Impurity 76 (CAS CATO-C4X-112876)
- N-(Benzo[d][1,3]dioxol-5-ylmethyl)-5,6-dimethyl-2-(pyridin-3-yl)thieno[2,3-d]pyrimidin-4-amine (CAS 796052-04-5)
- N-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)-4-((2-methylpiperidin-1-yl)sulfonyl)benzamide (CAS 850935-88-5)
- N'-(4-Methoxybenzylidene)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carbohydrazide (CAS 332390-41-7)
- Empagliflozin impurity 158 (CAS 226213-72-5)
- Ataluren Impurity 16 (CAS CATO-C4X-300616)
- Warfarin Impurity 16 (CAS CATO-C4X-142916)
- 9-Chlorospiro[benzo[c]fluorene-7,9'-fluorene] (CAS 1800333-59-8)
- 3-(4-Methoxyphenyl)-4-thiomethylpropiophenone (CAS 898775-70-7)
- Benidipine Impurity 78 (CAS CATO-C4X-112078)
- 6-Phenoxypicolinic acid (CAS 51362-40-4)
- spiro[6H-[1,3]dioxolo[4,5-f]isoindole-7,1-cyclopropane]-5-one (CAS 1990536-33-8)
- N-(2,6-dichlorophenyl)-2-fluorobenzamide (CAS 304884-73-9)
- Tetrapeptide-3 (CAS 827306-97-8)
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