Ruxolitinib Impurity 154 CAS 1270424-30-0
| CAS No. | 1270424-30-0 |
| Molecular Formula | C8H14N2 |
| Molecular Weight | 138.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Ruxolitinib Impurity 154 (CAS 1270424-30-0) is a certified pharmaceutical impurity reference standard with the molecular formula C8H14N2 and a molecular weight of 138.21 g/mol.
Based on its molecular formula C8H14N2, Ruxolitinib Impurity 154 contains a nitrile group; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 138.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H14N2 |
| Molecular Weight | 138.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 125 (CAS CATO-C4X-2058125)
- Ruxolitinib Impurity 16 (CAS 28791-95-9)
- Ruxolitinib Impurity 122 (CAS CATO-C4X-2058122)
- Ruxolitinib Impurity 59 (CAS 2802349-76-2)
- Ruxolitinib impurity 227 (CAS 350483-64-6)
- Ruxolitinib Impurity 60 (CAS CATO-C4X-205860)
- Ruxolitinib Impurity 124 (CAS CATO-C4X-2058124)
- Ruxolitinib Impurity 233 (CAS CATO-C4X-2058233)
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