Clarithromycin EP Impurity G CAS 127182-44-9
| CAS No. | 127182-44-9 |
| Molecular Formula | C39H72N2O13 |
| Molecular Weight | 776.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Clarithromycin EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Clarithromycin EP Impurity G (CAS 127182-44-9) is a certified pharmaceutical impurity reference standard with the molecular formula C39H72N2O13 and a molecular weight of 776.99 g/mol.
The molecular framework of Clarithromycin EP Impurity G (C39H72N2O13) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C39H72N2O13 |
| Molecular Weight | 776.99 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 2 |
Related Clarithromycin Standards
- Clarithromycin EP Impurity O (CAS 127252-80-6)
- Clarithromycin Impurity 22 (CAS CATO-C4X-100222)
- Clarithromycin EP Impurity A (CAS 124412-58-4)
- Clarithromycin Impurity 19 (CAS CATO-C4X-100219)
- Clarithromycin Impurity 20 (CAS 118074-07-0)
- Clarithromycin 9-Oxime (CAS 103450-87-9)
- Clarithromycin EP Impurity C (CAS 127253-06-9)
- Clarithromycin EP Impurity L (CAS 127253-05-8)
Recommended Standards
- Azithromycin Impurity P (CAS CATO-C4X-100352)
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