Neratinib Impurity 3 CAS CATO-C4X-11343
| CAS No. | CATO-C4X-11343 |
| Molecular Formula | C30H29ClN6O4 |
| Molecular Weight | 573.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Neratinib Impurity 3 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Neratinib Impurity 3 (CAS CATO-C4X-11343) is a certified pharmaceutical impurity reference standard with the molecular formula C30H29ClN6O4 and a molecular weight of 573.04 g/mol.
Based on its molecular formula C30H29ClN6O4, Neratinib Impurity 3 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 573.04 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Neratinib Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H29ClN6O4 |
| Molecular Weight | 573.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Neratinib Standards
- Neratinib Impurity 15 (CAS 1376615-55-2)
- Neratinib Impurity 16 (CAS 1376619-94-1)
- Neratinib Impurity 4 (CAS CATO-C4X-11344)
- Neratinib Impurity 49 (CAS 3050754-68-9)
- Neratinib Impurity 19 (CAS 1376619-98-5)
- Neratinib Impurity 35 (CAS CATO-C4X-113435)
- Neratinib-d6 (CAS 1259519-18-0)
- Neratinib Impurity 45 (CAS CATO-C4X-113445)
Recommended Standards
- Brivudine Triphosphate (CAS 77222-61-8)
- N-{[(4-chlorophenyl)carbamoyl]amino}-4-[4-(diphenylmethyl)piperazine-1-carbonyl]-5-methyl-1,2-oxazole-3-carboxamide (CAS 338408-78-9)
- Lusutrombopag Impurity 37 (CAS CATO-C4X-208437)
- 1-(2-(4-Bromo-2-chlorophenoxy)ethyl)-4-((tert-butyldiphenylsilyl)oxy)piperidine (CAS 1704080-89-6)
- Paraben Impurity 6 (CAS CATO-C4X-25696)
- CAS CATO-C3D-263214 (CAS CATO-C3D-263214)
- Methotrexate Impurity 26 (CAS CATO-C4X-115426)
- Disperse Orange 3 (CAS 730-40-5)
- 79917-39-8 2-Nitrosopyrimidine DTXSID80559647 (CAS 79917-39-8)
- N-(3-(3-Hydroxyprop-1-yn-1-yl)pyridin-2-yl)pivalamide (CAS 1203499-45-9)
- 1-(methoxy-d3)-2-nitrobenzene (CAS 29809-22-1)
- 7-Bromo-4-fluorobenzo[d]thiazol-2-amine (CAS 942473-90-7)
- (3-Aminobenzofuran-2-yl)(3-chloro-4-methoxyphenyl)methanone (CAS 889997-15-3)
- Osteoblast Activating Peptide (mouse, rat) (H-7262.0500) (CAS 1222950-80-2)
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