Nebivolol Impurity 45 CAS 129050-26-6
| CAS No. | 129050-26-6 |
| Molecular Formula | C11H11FO2 |
| Molecular Weight | 194.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nebivolol Impurity 45.
Nebivolol Impurity 45 (CAS 129050-26-6) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11FO2 and a molecular weight of 194.20 g/mol.
The molecular framework of Nebivolol Impurity 45 (C11H11FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nebivolol Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H11FO2 |
| Molecular Weight | 194.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
Related Nebivolol Standards
- Nebivolol Impurity 42 (CAS 197706-50-6)
- Nebivolol Impurity 43 (CAS 129050-23-3)
- Nebivolol Impurity 44 (CAS 197706-51-7)
- Nebivolol Impurity 74 (CAS CATO-C4X-196874)
- Nebivolol Impurity 25 (CAS 944904-25-0)
- Nebivolol Impurity 26 (CAS 93340-05-7)
- Nebivolol Impurity 50 (CAS 99199-62-9)
- Nebivolol Impurity 1 (CAS 1346562-34-2)
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