Nebivolol Impurity 44 CAS 197706-51-7
| CAS No. | 197706-51-7 |
| Molecular Formula | C11H11FO2 |
| Molecular Weight | 194.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nebivolol Impurity 44 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Nebivolol Impurity 44 (CAS 197706-51-7), a pharmacopoeial impurity reference standard (molecular formula C11H11FO2, MW 194.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Nebivolol Impurity 44 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 194.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11FO2 |
| Molecular Weight | 194.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Halogen Content | F-containing |
Related Nebivolol Standards
- Nebivolol Impurity 42 (CAS 197706-50-6)
- Nebivolol Impurity 43 (CAS 129050-23-3)
- Nebivolol Impurity 45 (CAS 129050-26-6)
- Nebivolol Impurity 74 (CAS CATO-C4X-196874)
- Nebivolol Impurity 25 (CAS 944904-25-0)
- Nebivolol Impurity 26 (CAS 93340-05-7)
- Nebivolol Impurity 50 (CAS 99199-62-9)
- Nebivolol Impurity 1 (CAS 1346562-34-2)
Recommended Standards
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- Kynurenic Acid-d5 (CAS 350820-13-2)
- Aripiprazole Impurity 71 (CAS CATO-C4X-100871)
- Isavuconazole Impurity 64 xTrifluoroacetate（Easy to absorb moisture） (CAS 2832083-17-5（free base))
- Phytomenadione/Vitamin K1 Impurity 93 (CAS CATO-C4X-220793)
- 2-(Cyclopentylamino)-2-phenylethan-1-ol (CAS 92687-06-4)
- Ethyl (1R,3S,4S)-4-((tert-butyldimethylsilyl)oxy)-3-fluorocyclohexane-1-carboxylate (CAS 1715032-78-2)
- tert-Butyl (1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate (CAS 1932123-56-2)
- 2-(2-Aminophenyl)-6-methoxyquinoline-5,8-diol (CAS 61472-45-5)
- 3-Methoxyfuran (CAS 3420-57-3)
- (6-Chloropyridin-3-yl)(1,1-dioxidothiomorpholino)methanone (CAS 1154382-72-5)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
Why CATO?
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