Nebivolol Impurity 25 CAS 944904-25-0
| CAS No. | 944904-25-0 |
| Molecular Formula | C10H9FO3 |
| Molecular Weight | 196.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nebivolol Impurity 25.
Nebivolol Impurity 25 (CAS 944904-25-0) is a certified pharmaceutical impurity reference standard with the molecular formula C10H9FO3 and a molecular weight of 196.18 g/mol.
Nebivolol Impurity 25 (C10H9FO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Nebivolol Impurity 25 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H9FO3 |
| Molecular Weight | 196.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Nebivolol Standards
- Nebivolol Impurity 26 (CAS 93340-05-7)
- Nebivolol Impurity 42 (CAS 197706-50-6)
- Nebivolol Impurity 43 (CAS 129050-23-3)
- Nebivolol Impurity 44 (CAS 197706-51-7)
- Nebivolol Impurity 45 (CAS 129050-26-6)
- Nebivolol Impurity 74 (CAS CATO-C4X-196874)
- Nebivolol Impurity 1 (CAS 1346562-34-2)
- Nebivolol Impurity 20 (CAS 105300-40-1)
Recommended Standards
- 5-Fluorochromane-2-carboxylic acid (CAS 93339-99-2)
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- N-cyclopropyl-4-fluoro-2-nitroaniline (CAS 887351-37-3)
- Nafamostat Impurity 55 (CAS CATO-C4X-133255)
- Roxadustat Impurity 126 (CAS CATO-C4X-2213126)
- Phenylbutyrate Impurity 12 (CAS CATO-C4X-258312)
- Methyl 2-(5-((7-ethoxy-6-methoxyquinolin-4-yl)oxy)-3-methoxypyridin-2-yl)acetate (CAS 947763-55-5)
- 2-Bromo-4-isopropyl-6-methylpyrimidin-5-amine (CAS 2397624-02-9)
- 6,7-Dihydro-5H-cyclopenta[b]pyridin-6-amine dihydrochloride (CAS 1355328-35-6)
- 1-(Tetrahydro-2h-pyran-4-yl)prop-2-yn-1-amine (CAS 1487339-09-2)
- 3-Methyl-4-(2-oxopiperidin-1-yl)benzaldehyde (CAS 1260763-62-9)
- Ethyl 3-(difluoromethyl)cyclobutane-1-carboxylate (CAS 2120250-04-4)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com