Nebivolol Impurity 37(RS,SS) CAS 129101-34-4
| CAS No. | 129101-34-4 |
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nebivolol Impurity 37(RS,SS) is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Nebivolol Impurity 37(RS,SS) (CAS 129101-34-4) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26FNO4 and a molecular weight of 387.44 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Nebivolol Impurity 37(RS,SS) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 387.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nebivolol Impurity 37(RS,SS) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 107 (CAS 99200-13-2)
- Nebivolol Hydrochloride EP Impurity A (CAS 1696472-15-7)
- Nebivolol EP Impurity A (CAS 1416402-13-5)
- Nebivolol Impurity 52(RR,RS) (CAS 1696472-14-6)
- Nebivolol Impurity 33(SS,SR) (CAS 129101-35-5)
- Nebivolol Impurity 40 (CAS CATO-C4X-196840)
- Nebivolol Impurity 36 (CAS 129101-33-3)
- Nebivolol Impurity 12（RS,SR） (CAS 119365-30-9)
Recommended Standards
- (4-(1H-Pyrrol-1-yl)phenyl)(4-(3-methyl-[1,2,4]triazolo[4,3-a]pyrazin-8-yl)piperazin-1-yl)methanone (CAS 2034268-25-0)
- Fmoc-Phe-OH (CAS 35661-40-6)
- 3-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(4-propoxybenzyl)propanamide (CAS 1031599-03-7)
- Nemonoxacin Impurity 88 (CAS CATO-C4X-312888)
- Eszopiclone Impurity 27 (CAS 1216659-29-8)
- Articaine Impurity 25 (CAS CATO-C4X-191225)
- Risperidone EP Impurity C ((S)-Isomer) (CAS 147663-01-2)
- (3-Bromophenyl)(4-fluoro-2-methylphenyl)methanol (CAS 1282206-43-2)
- 76576-68-6 (~7~Li)Lithium hydroxide--water (1/1/1) DTXSID70635505 (CAS 76576-68-6)
- 2-Methyl-4-(2,2,2-trifluoroethoxy)aniline hydrochloride (CAS 1431962-93-4)
- 2-[4-(2-Fluorophenyl)-1,3-thiazol-2-yl]-3-(4-oxo-4H-chromen-3-yl)acrylonitrile (CAS 861211-44-1)
- 5-Fluoro-n-(piperidin-4-ylmethyl)pyridin-2-amine hydrochloride (CAS 2680615-59-0)
- 4-Cyano-3-ethylphenylboronic acid (CAS 911210-52-1)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
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