Nebivolol Impurity 107 CAS 99200-13-2
| CAS No. | 99200-13-2 |
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nebivolol Impurity 107.
CATO supplies Nebivolol Impurity 107 (CAS 99200-13-2), a pharmacopoeial impurity reference standard (molecular formula C22H26FNO4, MW 387.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Nebivolol Impurity 107 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 387.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Hydrochloride EP Impurity A (CAS 1696472-15-7)
- Nebivolol Impurity 37(RS,SS) (CAS 129101-34-4)
- Nebivolol EP Impurity A (CAS 1416402-13-5)
- Nebivolol Impurity 52(RR,RS) (CAS 1696472-14-6)
- Nebivolol Impurity 33(SS,SR) (CAS 129101-35-5)
- Nebivolol Impurity 40 (CAS CATO-C4X-196840)
- Nebivolol Impurity 36 (CAS 129101-33-3)
- Nebivolol Impurity 12（RS,SR） (CAS 119365-30-9)
Recommended Standards
- (4-(1H-Pyrrol-1-yl)phenyl)(4-(3-methyl-[1,2,4]triazolo[4,3-a]pyrazin-8-yl)piperazin-1-yl)methanone (CAS 2034268-25-0)
- Fmoc-Phe-OH (CAS 35661-40-6)
- Nemonoxacin Impurity 88 (CAS CATO-C4X-312888)
- Nemonoxacin Impurity 46 (CAS CATO-C4X-312846)
- Tirofiban Impurity 106 HCl (CAS CATO-C4X-1254106)
- Brimonidine Impurity 29 (CAS CATO-C4X-156629)
- Polaprezinc impurity 31 (CAS CATO-C4X-182131)
- (S)-2-Amino-N-(2-iodobenzyl)-N-isopropylpropanamide (CAS 1353996-51-6)
- 3-Bromo-4-chloro-2-methyl-1-(p-tolyl)-6,7-dihydro-1h-indole-5-carbaldehyde (CAS 326916-09-0)
- 661472-41-9 BIW199E18V Relamorelin [USAN:INN] UNII-BIW199E18V BIM28131 BIM-28131 Relamorelin 4-Piperidinecarboxamide, 3-benzo(b)thien-3-yl-N-(4-piperidinylcarbonyl)-D-alanyl-D-tryptophyl-L-phenylalanyl-4-amino- Relamorelin [INN] Relamorelin [WHO-DD] RM 131 RM131 RM-131 (CAS 661472-41-9)
- Uracil-5-d1 (CAS 24897-50-5)
- 7-Chlorothiazolo[5,4-d]pyrimidin-2-ol (CAS 120209-33-8)
- Palbociclib Impurity 56 (CAS 571189-51-0)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
Why CATO?
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