Nebivolol Impurity 33(SS,SR) CAS 129101-35-5
| CAS No. | 129101-35-5 |
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 387.44 g/mol gives Nebivolol Impurity 33(SS,SR) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Nebivolol Impurity 33(SS,SR) (CAS 129101-35-5) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26FNO4 and a molecular weight of 387.44 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Nebivolol Impurity 33(SS,SR) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 387.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nebivolol Impurity 33(SS,SR) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 107 (CAS 99200-13-2)
- Nebivolol Hydrochloride EP Impurity A (CAS 1696472-15-7)
- Nebivolol Impurity 37(RS,SS) (CAS 129101-34-4)
- Nebivolol EP Impurity A (CAS 1416402-13-5)
- Nebivolol Impurity 52(RR,RS) (CAS 1696472-14-6)
- Nebivolol Impurity 40 (CAS CATO-C4X-196840)
- Nebivolol Impurity 36 (CAS 129101-33-3)
- Nebivolol Impurity 12（RS,SR） (CAS 119365-30-9)
Recommended Standards
- 3-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(4-propoxybenzyl)propanamide (CAS 1031599-03-7)
- N-Cyclohexyl-4-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)piperazine-1-carboxamide (CAS 1049444-29-2)
- Methyl N-(tert-butoxycarbonyl)-O-tosyl-D-allothreoninate (CAS 112380-21-9)
- (S)-N-Boc-L-homoserine Methyl Ester Tosylate (CAS 120042-09-3)
- Meloxicam impurity 13 (CAS 130262-92-9)
- Niraparib Impurity N3 (CAS 1203686-41-2)
- Opicapone Impurity 80 (CAS CATO-C4X-240480)
- 4-(N,N-dimethylsulfamoyl)morpholine-3-carboxylic acid (CAS 1316218-55-9)
- 5-(2-Bromo-5-fluorophenyl)-1H-pyrazol-3-amine (CAS 1137456-13-3)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
- 2-Amino-2-(pyrazolo[1,5-b]pyridazin-3-yl)acetic acid (CAS 1461705-49-6)
- 6-Ethyl-5-methyl-2-(methylamino)pyrimidin-4(3h)-one (CAS 1342204-94-7)
- (4-Methoxy-benzothiazol-2-yl)-hydrazine (CAS 53065-23-9)
- 3AEEA-Semaglutide(Endo-AEEA-Semaglutide) (CAS CATO-C4X-2226265)
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