Nebivolol Impurity 52(RR,RS) CAS 1696472-14-6
| CAS No. | 1696472-14-6 |
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 387.44 g/mol gives Nebivolol Impurity 52(RR,RS) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nebivolol Impurity 52(RR,RS) (CAS 1696472-14-6, C22H26FNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nebivolol Impurity 52(RR,RS) (C22H26FNO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nebivolol Impurity 52(RR,RS) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | 387.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 107 (CAS 99200-13-2)
- Nebivolol Hydrochloride EP Impurity A (CAS 1696472-15-7)
- Nebivolol Impurity 37(RS,SS) (CAS 129101-34-4)
- Nebivolol EP Impurity A (CAS 1416402-13-5)
- Nebivolol Impurity 33(SS,SR) (CAS 129101-35-5)
- Nebivolol Impurity 40 (CAS CATO-C4X-196840)
- Nebivolol Impurity 36 (CAS 129101-33-3)
- Nebivolol Impurity 12（RS,SR） (CAS 119365-30-9)
Recommended Standards
- 3-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(4-propoxybenzyl)propanamide (CAS 1031599-03-7)
- N-Cyclohexyl-4-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)piperazine-1-carboxamide (CAS 1049444-29-2)
- Methyl N-(tert-butoxycarbonyl)-O-tosyl-D-allothreoninate (CAS 112380-21-9)
- (4-(1H-Pyrrol-1-yl)phenyl)(4-(3-methyl-[1,2,4]triazolo[4,3-a]pyrazin-8-yl)piperazin-1-yl)methanone (CAS 2034268-25-0)
- Revefenacin impurity 92 (CAS CATO-C4X-203192)
- Piracetam impurity 32 HCl (CAS CATO-C4X-123532)
- Rimegepant Impurity 53 DiHCl (CAS CATO-C4X-248753)
- 1-((1-(4-Fluorophenyl)-1H-tetrazol-5-yl)methyl)-3-(2-methoxyphenyl)urea (CAS 897623-99-3)
- 2-(4-Chlorophenyl)-1-((4-methylbenzyl)oxy)-6-nitro-1H-benzo[d]imidazole (CAS 282523-17-5)
- 2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindoline-5-carbaldehyde (CAS 2582979-82-4)
- 4-(Difluoromethyl)-2,5-diiodo-3-nitropyridine (CAS 1806897-18-6)
- 2-Benzyl-5-chloro-4-methoxypyridazin-3(2H)-one (CAS 77541-65-2)
- 1-(6-Bromopyridin-2-yl)-2,2,2-trifluoroethan-1-amine (CAS 886364-60-9)
- C-Peptide (human) (CAS 33017-11-7)
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