阿立哌唑杂质22 CAS 129722-22-1
| CAS No. | 129722-22-1 |
| Molecular Formula | C23H26Cl3N3O2 |
| Molecular Weight | 482.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 482.83 g/mol gives 阿立哌唑杂质22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, 阿立哌唑杂质22 (CAS 129722-22-1, C23H26Cl3N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, 阿立哌唑杂质22 (C23H26Cl3N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 482.83 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), 阿立哌唑杂质22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H26Cl3N3O2 |
| Molecular Weight | 482.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
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- 2-Ethylimidazo[1,2-a]pyridine-3-carboxylic acid (CAS 1266866-71-0)
- (3Z)-1-[(3,4-Dichlorophenyl)methyl]-3-(methoxyimino)-2,3-dihydro-1H-indol-2-one (CAS 477853-28-4)
- (3-Chlorobenzylidene)acetone (3E)-4-(3-chlorophenyl)but-3-en-2-one 20766-36-3 4-(3-chlorophenyl)but-3-en-2-one (CAS 20766-36-3)
- Metoclopramide Impurity 125 (CAS 476615-04-0)
- 3,4-Bis(2-methoxyethoxy)benzonitrile (CAS 80407-68-7)
- Lixisenatide (CAS 320367-13-3)
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