Metoclopramide Impurity 125 CAS 476615-04-0
| CAS No. | 476615-04-0 |
| Molecular Formula | C12H17ClN2O2 |
| Molecular Weight | 256.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Metoclopramide Impurity 125 (CAS 476615-04-0, C12H17ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Metoclopramide Impurity 125 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 256.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H17ClN2O2 |
| Molecular Weight | 256.73 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Metoclopramide Standards
- Metoclopramide Impurity 17 (CAS CATO-C4X-141517)
- Metoclopramide EP Impurity B (CAS 4093-31-6)
- Metoclopramide Impurity 24 (CAS CATO-C4X-141524)
- Metoclopramide (CAS CATO-C4X-141557)
- Metoclopramide impurity 64 (CAS CATO-C4X-141564)
- Metoclopramide impurity 82 (CAS CATO-C4X-141582)
- Metoclopramide impurity 70 (CAS 102313-35-9)
- Metoclopramide Impurity 121 (CAS CATO-C4X-1415121)
Recommended Standards
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- Amphotericin B Impurity 7 (CAS CATO-C4X-18447)
- Prusogliptin impurity 3 (CAS CATO-C4X-32843)
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- 2-Cyclopropoxy-4-iodo-1-nitrobenzene (CAS 1243359-97-8)
- Fenbendazole Sulfone-D3 (CAS 1228182-49-7)
- 1-ethenyl-3-methyl-1h-imidazol-3-ium methyl sulfate 5661-55-2 AR-1C2791 (CAS 5661-55-2)
- 4-(((3,5-Dimethoxybenzyl)thio)methyl)thiazol-2-amine (CAS 1019111-59-1)
- 3-BROMO-N-(1-HYDROXY-2-METHYLPROPAN-2-YL)BENZAMIDE (CAS 211388-38-4)
- Semaglutide impurity 86 (CAS CATO-C4X-152686)
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