Tamoxifen EP Impurity A CAS 13002-65-8
| CAS No. | 13002-65-8 |
| Molecular Formula | C26H29NO |
| Molecular Weight | 371.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 371.51 g/mol gives Tamoxifen EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Tamoxifen EP Impurity A (CAS 13002-65-8, C26H29NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Tamoxifen EP Impurity A is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 371.51 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tamoxifen EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H29NO |
| Molecular Weight | 371.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Nitrogen Atoms | 1 |
Related Tamoxifen Standards
- Tamoxifen 2-Isomer (CAS 7728-73-6)
- Tamoxifen Impurity 29 (CAS CATO-C4X-123329)
- Tamoxifen EP Impurity E (Mixture of Z and E Isomers) (CAS CATO-C4X-12336)
- Tamoxifen (CAS 10540-29-1)
- Tamoxifen Citrate Impurity 25 (CAS 114828-90-9)
- Tamoxifen Impurity 23 (CAS CATO-C4X-123323)
- Tamoxifen Impurity 15 (CAS 157698-32-3)
- Tamoxifen Citrate - Impurity D (CAS 197251-11-9)
Recommended Standards
- Clomifene EP Impurity A (CAS 19957-52-9)
- Abiraterone Pregnenolone-16-Ene Acetate Oxime (CAS 2174-13-2)
- Glycopyrrolate Impurity 19 (CAS CATO-C4X-143119)
- (3S,8R,9S,10R,13S,14S)-17-((Z)-1-(hydroxyimino)ethyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate (CAS 23549-26-0)
- Losartan EP Impurity H (CAS 133909-99-6)
- Carvedilol impurity 8 (CAS 18181-71-0)
- Cephalexin Impurity 18 (CAS 34632-04-7)
- 4-Chloro-1-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 65974-01-8)
- 5-(Trifluoromethyl)picolinonitrile (CAS 95727-86-9)
- 5-(4-Chloro-3-ffluorophenyl)-1,3-oxazole (CAS 2002638-39-1)
- 4-Bromo-1-iodo-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]indene (CAS 2088850-45-5)
- 2-(4-tert-Butyl-phenyl)-piperazine (CAS 910444-34-7)
- 1-(2-{5,6,7-trimethylpyrazolo[1,5-a]pyrimidin-2-yl}thiophen-3-yl)-1H-pyrrole (CAS 478039-43-9)
- Semaglutide impurity 106 (CAS CATO-C4X-2226106)
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