Tryptophan EP Impurity A CAS 132685-02-0
| CAS No. | 132685-02-0 |
| Molecular Formula | C24H26N4O4 |
| Molecular Weight | 434.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tryptophan EP Impurity A.
As a process- or degradation-related impurity, Tryptophan EP Impurity A (CAS 132685-02-0, C24H26N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H26N4O4, Tryptophan EP Impurity A contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 434.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H26N4O4 |
| Molecular Weight | 434.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 4 |
Related Tryptophan Standards
- Tryptophan Impurity 52 (CAS CATO-C4X-137352)
- Tryptophan impurity 37 (CAS CATO-C4X-137337)
- Tryptophan impurity 39 (CAS CATO-C4X-137339)
- Tryptophan impurity 40 (CAS CATO-C4X-137340)
- Tryptophan EP Impurity J (CAS 164068-19-3)
- Tryptophan impurity 41 (CAS CATO-C4X-137341)
- Tryptophan impurity 42 (CAS CATO-C4X-137342)
- Tryptophan Impurity 15 (CAS 180509-18-6)
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