o-Toluenesulfonyl Chloride (contains ca. 23% isomer) CAS 133-59-5
| CAS No. | 133-59-5 |
| Molecular Formula | C7H7ClO2S |
| Molecular Weight | 190.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
o-Toluenesulfonyl Chloride (contains ca. 23% isomer) (CAS 133-59-5) is a high-purity analytical reference standard with the molecular formula C7H7ClO2S and a molecular weight of 190.65 g/mol.
o-Toluenesulfonyl Chloride (contains ca. 23% isomer) (C7H7ClO2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7ClO2S |
| Molecular Weight | 190.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related o Standards
- p-Toluenesulfonyl Chloride (CAS 98-59-9)
- p-Toluenesulfonyl Hydrazide (CAS 1576-35-8)
- m-toluenesulfonyl chloride (CAS 1899-93-0)
- p-Toluenesulfonyl isocyanate (CAS 4083-64-1)
- 4-Toluenesulfonyl cyanide (CAS 19158-51-1)
- 455-16-3 4-Toluenesulfonyl fluoride Benzenesulfonyl fluoride, 4-methyl- 4-Methylbenzenesulfonyl fluoride p-Toluenesulfonyl fluoride p-Toluenesulphonyl fluoride 4-11-00-00375 (Beilstein Handbook Reference) BRN 2208423 EINECS 207-238-6 p-Methylbenzenesulfonyl fluoride p-Methylphenylsulfonyl fluoride NSC 2749 Phenylmethylsulfonyl fluoride Toluene-4-sulfonyl fluoride Toluene-p-sulphonyl fluoride 4-Tolylsulfonyl fluoride Tosyl fluoride (CAS 455-16-3)
- 1-(p-Toluenesulfonyl)aziridine 1-(p-Toluenesulfonyl)ethylenimine 1-(p-Tolylsulfonyl)aziridine 1-Tosylaziridine 1-[(4-Methylphenyl)sulfonyl]aziridine 3634-89-7 N-(p-Toluenesulfonyl)aziridine N-(p-Tolylsulfonyl)aziridine N-Tosylaziridine N-[(4-Methylphenyl)sulfonyl]aziridine N-p-Tosylaziridine (CAS 3634-89-7)
- 1-(P-Toluenesulfonyl)pyrrole-2-aldehyde (CAS 102619-05-6)
Recommended Standards
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- N-(5-bromopyridin-3-yl)-4-methylbenzenesulfonamide (CAS 1216-97-3)
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